Sunday, January 13, 2008

Biochemistry, Pathways, and Addiction

An interesting story in The Economist regarding what appears to be a breakthrough study conducted by Chinese researchers on the science of addiction:

A group of Chinese scientists has discovered the main biochemical pathways in drug addiction—and without having to do a single experiment:

MODERN biology has a lot of “omes”. The genome—all the genes that go to make up an organism—is a familiar idea. The proteome—all the different proteins—is becoming so. But there are also the transcriptome (RNA), the glycome (sugars), the lipidome (fats) and the metabolome (all the miscellaneous odds and ends not covered by the others). And then there is the bibliome—all the mentions in research papers of known biomolecules. There are now so many of these papers, and the databases linking them are so good, that it is possible to use scientific methods to investigate the bibliome in its own right, just as any of the other, wetter “omes” may be investigated. Which is exactly what a group of researchers from Peking University, led by Wei Liping, have done to get at the biochemical heart of drug addiction.

Dr Wei and her colleagues wanted to answer three questions. First, what are the genes and biochemical pathways in addiction? Second, does addiction to different substances involve the same core biochemical mechanisms? Third, does anything in those mechanisms explain why addiction is so hard to shake off?

Many people, of course, have asked these questions before, and partial answers have emerged. What Dr Wei hoped to do was to take these fragmentary answers and patch them together to make something approaching the whole truth. And, in a paper just published in the Public Library of Science, she seems to have managed just that.

It looks good on paper

Dr Wei's group looked at more than 1,000 studies of the biochemistry and genetics of drug addiction. They were interested in the four sorts of drug reckoned most addictive: alcohol, cocaine, nicotine and opiates (heroin, methadone and so on). About 1,500 genes were implicated by one or more of the studies, but in only 396 cases was that implication backed by at least two independent lines of evidence. It was on these confirmed cases that Dr Wei concentrated her fire.

Biochemistry is about pathways and networks of pathways. A pathway is a series of enzymes (each of which is encoded in a gene) that perform a task in sequence, like workers on an assembly line. Dr Wei therefore ran her 396 genes through a database of all known pathways to see which involved several enzymes encoded by those genes.

She found 18 that were involved in addiction to at least one type of drug. Five, however, were common to all four types, and these five pathways therefore look as though they are at the core of the process of addiction. Three of the five were already under suspicion. Dr Wei's result provided strong statistical evidence to back up what had just been hunches. Two other pathways, however, had not previously been considered as being involved in addiction.
The existence of these five central pathways helps explain a lot about addiction. First, it gives weight to the belief that some people are more susceptible to all sorts of addiction than others are. That contrasts with the thought that addictions are substance-by-substance phenomena, though the two ideas are not mutually exclusive since changes in the 13 substance-specific pathways clearly also result in addiction.

Second, the particular pathways involved help to explain why addiction is so hard to reverse. Several of them take part in strengthening the connections between nerve cells, which is the underlying basis of learning. Unlearning something by breaking these connections is hard.

Third, Dr Wei was able to link the five central pathways together into a network, and show that this network has four positive-feedback loops in it. Work on other species in other contexts suggests that the mixture of loops she found was one that often results in rapid and irreversible biological processes—which is exactly what is seen in addiction.

None of this, of course, directly helps the addict, though it reinforces the message that it is better not to start taking these drugs in the first place. But working out how the addiction machine operates may point those looking for therapies in the right direction. And this study also shows that the old cry “more research is necessary” is not always true. Sometimes all you need to do is look at what you already have in a different way.

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gold key casino -
grand hotel casino -
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home casino -
jackpot city -
joyland casino -
lucky nugget -
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magic oasis -
mapau -
mapau bingo -
mapau de -
maple casino -
miami beach -
millionaire casino -
monaco gold casino -
new york casino -
orbital casino -
playgate casino -
playgate poker -
poker forum championship -
poker ocean -
poker show -
poker time -
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prestige casino -
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refer back -
river belle -
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royal plaza casino -
royal vegas -
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showdown casino -
silver dollar -
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sun vegas -
super slots -
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usa casino -
vegas 7 casino -
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you bingo -
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50 stars casino -
888 -
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ace club -
bet 19 -
bet euro -
bet game day -
bet on games -
bet on races -
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black widow casino -
cabaret club casino -
caribbean sun poker -
car sands -
casino france net -
casino king -
casino las vegas -
casino onliner -
casino on net -
casino profit share -
challenge casino -
cirrus casino -
club player casino -
cool cat casino -
cs casino -
empire poker -
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fair deal sports -
fair poker -
fast win casino -
five card charlie -
gambling wages -
geisha lounge -
golden reef casino -
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good as gold casino -
grand aces -
grand banks casino -
i play tournaments -
jackpots in a flash -
king solomons -
kiwi bingo -
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kiwi casino -
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luck n roll casino -
mad bingo -
magic box casino -
miami paradise -
miss bingo -
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music hall casino -
noble poker -
nostalgia casinos -
omni casino -
palace of chance -
party bingo -
party casino -
party casinos -
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peach casino -
piggs casino -
piggs peak -
planet luck -
poker 333 -
poker metro -
poke round -
rich webmaster -
river nile casino -
roxy palace -
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ruby fortune -
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slots alley casino -
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spass kasino -
spin palace -
spin palace poker -
sports interaction -
star luck casino -
sterling house casino -
sun poker -
swiss casino -
the sands -
the sands of caribbean -
tiki bingo -
uk casino club -
vegas splendido -
vip casinos -
vip horses -
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vip profits -
vip soccer -
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wager junction -
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wssb casino -
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action gold -
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all jackpots -
all slots -
all star affiliates -
amber coast casino -
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bingo 770 -
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break away casino -
bright right -
cash wave -
casino domain -
casino euro -
casino lucky dog -
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casino verano -
casino webcam -
cherry casino -
city club casino -
cyber sportsbook -
diamond gal -
earn united -
first web casino -
fortune junction -
geisha bingo -
giant vegas -
go casino -
gold betting -
grand bay -
grand bay poker -
grand casino royale -
grand riviera -
hampton casino -
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internet bingo -
jackpot factory -
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jackpot wheel -
jet bingo -
jupiter club -
king neptunes casino -
lady dream -
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jey said...

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online vegas -
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paradise affiliates -
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players vegas -
play united -
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portofino casino -
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revenue giants -
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sci fi casino -
shark casino -
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slots village -
speed bet -
the six shooter -
the star casino -
tiger gaming -
top card casino -
top line bingo -
trident lounge -
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triple win -
ultimate bet -
vegas break casino -
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absolute poker -
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club euro casino -
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diamond deal casino -
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euro poker -
festive bingo -
galactic bingo -
gaming income -
giga slot -
global player -
gran casino espana -
holdem poker -
i net bet -
inter champs -
island poker -
jackpot palace -
juegos 65 -
ladies bingo -
las seters -
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metro casino -
my bookie -
nine -
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pacific poker -
paradise 8 -
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play 65 -
play and deal -
players club casino -
poker -
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pure slots -
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pyramid casino -
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sia casino -
slot fever casino -
slot land -
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stars and stripes bingo -
sun palace casino -
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tcads -
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touch stone poker -
true earnings -
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video poker classic -
24h poker -
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777 dragon -
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aces high -
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arthurian casino -
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caribbean gold -
casino blasters -
casino bleu blanc rouge -
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casino kingdom -
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cinema casino -
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diamond casino -
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flamingo club -
fortune affiliates -
fortune lounge -
fortune room -
gaming club -
gaming club poker -
gaming club uk -
golden palace -
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golden tiger casino -
golden tiger poker -
gold nugget casino -
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grand hotel casino -
grand online -
hammers casino -
havana club -
home casino -
jackpot city -
lucky emperor -
lucky nugget -
lucky nugget casino uk -
lucky nugget poker -
maple casino -
millionaire casino -
online casino -
orbital casino -
phoenician casino -
platinum play -
play 4 free -
poker forum challenge -
poker ocean -
poker rewards -
poker time -
refer back -
rewards parking -
river belle -
river belle poker -
royal vegas -
royal vegas poker -
seven sultans -
showdown casino -
silver dollar -
silver dollar casino -
strike it lucky casino -
sun vegas -
super slots -
super slots bingo -
titan poker -
vegas affiliates -
vegas country casino -
vegas palms -
vegas partner -
vegas red -
vegas towers -
vegas villa -
virtual city casino -
virtual city poker -
yukon gold casino -
zodiac casino -
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3 diamonds casino -
49er casino -
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888 -
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ace club -
black widow casino -
caribbean sun poker -
carnival casino -
car sands -
casino fortune -
casino fortune uk -
casino france net -
casino king -
casino las vegas -
casino mb -
casino onliner -
casino on net -
casino pays -
casino profit share -
cd casino -
cd poker -
challenge casino -
cirrus casino -
club dice casino -
club dice poker -
club player casino -
cool cat casino -
cs casino -
diamond club casino -
diamond club poker -
empire poker -
ep -
fair poker -
gambling wages -
geisha lounge -
golden reef casino -
golden riviera casino -
golden riviera poker -
gold gate casino -
gold key casino -
grand aces -
grand banks casino -
i play tournaments -
joyland casino -
luck n roll casino -
mad bingo -
magic box casino -
magic oasis -
mapau -
mapau bingo -
mapau de -
miami beach -
miami paradise casino -
miss bingo -
monaco gold casino -
music hall casino -
new york casino -
noble poker -
nostalgia casinos -
omni casino -
palace of chance -
party bingo -
party casino -
party poker -
peach casino -
planet luck -
playgate casino -
playgate poker -
poker metro -
poke round -
poker show -
prestige bingo -
prestige casino -
prestige poker -
rich webmaster -
river nile casino -
royal plaza casino -
ruby bingo -
ruby bingo uk -
s casino -
slots alley casino -
slots royale -
spass kasino -
sports interaction -
star luck casino -
sterling house casino uk -
sunny diamonds -
sun poker -
swiss casino -
the sands -
uk casino club -
usa casino -
vegas 7 casino -
vegas joker casino -
vegas slot casino -
wager junction -
windows casino -
you bingo -
all jackpots -
all slots -
all star affiliates -
aus vegas -
bella vegas -
bet 19 -
bet bet -
bet casino -
bet euro -
bet game day -
bet holdem -
bet on games -
bet on races -
bet wwts -
big bettys bingo -
bingo 777 -
bingo fantasy -
black pool bingo -
break away casino -
bright right -
cabaret club casino -
cash wave -
casino lucky dog -
casino pay check -
casino verano -
casino webcam -
city club casino -
cyber sportsbook -
diamond gal -
earn united -
fair deal sports -
fast win casino -
first web casino -
five card charlie -
fortune junction -
go casino -
gold betting -
good as gold casino -
grand bay -
grand bay poker -
grand casino royale -
grand riviera -
hotel casino network -
jackpot factory -
jackpot joy -
jackpots in a flash -
jackpot wheel -
jupiter club -
king neptunes casino -
king solomons -
kiwi bingo -
kiwi bingo uk -
kiwi casino -
kiwi casino poker -
lady dream -
lake palace -
mahjong time -
merlins magic casino -
mummys gold -
online vegas -
only bingo -
piggs casino -
piggs peak -
players vegas -
play united -
poker 333 -
poker share -
race track casino -
refer spot -
roxy palace -
roxy poker -
ruby fortune -
sail away casino -
sandpiper casino -
sci fi casino -
shark casino -
spin palace -
spin palace poker -
the six shooter -
the star casino -
tiki bingo -
top card casino -
top line bingo -
trident lounge -
trident poker -
triple win -
ultimate bet -
vegas break casino -
vegas experts -
vegas splendido -
vegas usa -
vip casinos -
vip horses -
vip poker -
vip profits -
vip soccer -
vip sports -
wager profits -
wssb casino -
wssb sport -
9 am -
9 games -
9 poker -
acf webmaster -
action gold -
action poker -
affiliate lounge -
amber coast casino -
apues tas -
atlantic lounge -
bet 365 -
bet 365 poker -
bet com -
bet max casino -
bet on usa -
bets son -
bing cabin -
bingo bank roll -
bingo cafe -
bingo for money -
bingo hall -
bingo liner -
bingo palace -
bingo program -
bingo reward -
bingo royalty -
bingos -
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capital bingo -
casino 365 -
casino 770 -
casino domain -
casino euro -
casino partouche -
cherry casino -
cindys poker -
crystal palace casino -
diamond deal casino -
el bingo -
festive bingo -
galactic bingo -
gaming income -
geisha bingo -
giant vegas -
giga slot -
gran casino espana -
hampton casino -
i net bet -
inter champs -
internet bingo -
jet bingo -
juegos 65 -
las vegas usa casino -
my bookie -
nine -
nine am -
nine games -
nine poker -
oasis casino -
oyna 65 -
paradise affiliates -
paradise poker -
play 65 -
play and deal -
poker -
poker affiliate -
poker cs -
poker in canada -
portofino casino -
pure slots -
purple lounge -
pyramid casino -
refer bingo -
revenue giants -
rock the wallet -
royal card club -
royal dice -
sierra star casino -
slot fever casino -
slot land -
slots -
slots cr -
slots plus -
slots village -
speed bet -
stars and stripes bingo -
sun palace casino -
tcads -
tiger gaming -
touch stone poker -
true earnings -
twin aces casino -
vegas online casino -
vics bingo -
video poker classic -
wild jack casino -
wild jack mobile -
wild jack poker -
winward casino -
24h poker -
24kt gold -
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400 affiliates -
absolute poker -
acropolis casinos -
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bet fred -
bingo promoter -
blackjack ballroom -
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casino blaster -
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casino controller -
casino reward -
casino rewards -
casino room -
celeb poker -
club euro casino -
club uk casino -
club usa casino -
cocoa casino -
da vincis gold -
ecard room -
euro poker -
flamingo club -
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global player -
golden palace -
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golden palace bingos -
golden palace mobile -
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gold nugget -
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grand online -
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grand onlines -
holdem poker -
island poker -
jackpot palace -
ladies bingo -
las seters -
lucky emperor -
metro casino -
online casino -
online casinos -
pacific poker -
paradise 8 -
paradise eight -
pharaohs casino -
phoenician casino -
phoenician casinos -
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players club casino -
poker room -
sia casino -
slots 24 -
strike it lucky -
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strike it luckys -
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sunset casino -
this is vegas -
vc casino -
vc poker -
vegas lucky -
vegas magic -
victor chandler casino -
virtual city -
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yukon gold -
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zodiac casino -
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aztec riches poker -
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casino classic -
casino classics -
casino kingdom -
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classic casino -
college poker championship -
desert dollar -
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diamond club -
diamond club casino -
diamond clubs -
fortune affiliate -
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fortune lounge -
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fortune room -
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fortune rooms -
golden tiger poker -
golden tiger poker casino -
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golden tigers poker -
grand prix lotto -

jey said...

grand prix lottos -
havana club -
havana club casino -
havana clubs -
kingdom casino -
lucky emperor casino -
lucky emperors -
lucky nugget -
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platinum play -
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platinum plays -
play 4 free -
poker forum championship -
poker reward -
poker rewards -
poker rewards casino -
poker time -
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poker times -
refer back -
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reward parking -
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river belle -
river belle casino -
river belle casinos -
river belles -
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royals vegas -
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seven sultan -
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vegas palm -
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vegas tower -
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vegas villa -
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vegas villas -
virtual city poker -
virtual city poker casino -
virtual city pokers -
virtual citys poker -
777 dragon -
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777 dragons -
ace high -
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aces high -
aces high casino -
all poker casino -
all pokers casino -
aposte -
arthurian casino -
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cameo casino -
cameos casino -
caribbean gold -
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caribbean golds -
casino bleu blanc rouge -
casino coin -
casino coins -
casino del rio -
casino del rios -
casino partner -
casino partners -
casino tropez -
cinema casino -
cinemas casino -
crazys vegas -
crazys vegas poker -
crazy vegas -
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crazy vegas pokers -
english habour -
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english habour poker -
english habour poker casino -
english habour pokers -
english habours -
english habours poker -
english habours uk -
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europa casino -
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gaming club -
gaming club casino -
gaming clubs -
gaming clubs casino -
gaming club uk -
hammer casino -
hammers casino -
home casino -
homes casino -
jackpot city -
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jackpot citys -
lucky nugget casino uk -
lucky nugget poker -
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seven seven seven dragon -
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super slot -
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casino fortune -
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cd casino -
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jey said...

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