Friday, January 18, 2008

A Tooth Instead of a Patch?

I’ve argued for a long time that the delivery of pharmaceutical TECHNOCORRECTIONS will have to come through some kind of patch that will exact a very painful cost for removal and/or through some under-the-skin mechanism that, again, will leave a hell of a mark. But now it looks like researchers have discovered how to insert teeth to deliver drugs that otherwise would not get taken. I’m not sure if it’s embedded deep enough to cause the pain and hardship necessary to prevent removal, but, if it can be, it sounds like we may have a winner because the tech is so much more precise.

. . . IntelliDrug, a project funded by the European Commission, has developed a system that delivers controlled drug doses at appropriate intervals, keeping the dose delivered within the exact therapeutic window. Better yet, it is easy to maintain and requires no invasive procedure.

The answer to the 2500 year-old compliance conundrum? A prosthetic tooth, just two molars in size, containing a reservoir, valve and programmable timing controls. It can even be controlled by infrared, which allows doctors to adjust doses during the course of treatment. Ultimately, it could allow patients on pain medication to self-medicate, if necessary.

“The oral cavity is very accessible, so the device can be easily installed, refilled or have its batteries replaced,” says Dr Ben Z Beiski, IntelliDrug co-inventor and project manager. “But passing the drug through the buccal (cheek) tissue also means much greater bioavailability.”

I have just got to work “bioavailability” and “buccal” into a conversation this long holiday weekend.

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